Aurora at the pole and equator overlapping functions of Aurora kinases Biology Diagrams
Aurora at the pole and equator overlapping functions of Aurora kinases Biology Diagrams For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review we discuss the biology of these kinases: structure, function, regulation and association with cancer. Methods and results: A literature search. Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their As described above, there are three classes of aurora kinases in multicellular organisms, including humans: Aurora A (a.k.a. Aurora 2) functions during prophase of mitosis and is required for correct duplication and separation of the centrosomes (the microtubule organising centres in eukaryotic cells). Aurora A activity is positively-regulated by the spindle protein TPX2, [4] [5] and has Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization. AurA favors the G2/M transition by promoting centrosome maturation and mitotic spindle assembly. AurB and AurC are chromosome-passenger complex proteins, crucial for
The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution.
Aurora kinases: Generators of spatial control during mitosis Biology Diagrams
During mitosis, Aurora kinases regulate the structure and function of the cytoskeleton and chromosomes and the interactions between these two at the kinetochore. They also regulate signalling by
Abstract. Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function
Roles of Aurora Kinases in Mitosis and Tumorigenesis Biology Diagrams
Aurora A is localized to spindle poles where it provides spatial information for spindle functions in prometaphase. Aurora A is a kinase that is highly related to Aurora B but the two kinases localize to distinct subcellular regions during mitosis . From prometaphase to anaphase Aurora A localizes to the two poles of the spindle, which are the